It’s estimated that five to eight million Americans use opioids to manage chronic pain (i.e., pain lasting longer than three months).1,2 Opioids are also used for acute pain, cancer-related pain, post-surgical pain and vascular pain.1 Though prescription opioids provide effective pain relief, this treatment is associated with significant risks—including fatal opioid overdose.1,3 Approximately 125 million prescriptions were written for opioids in 2023, but research published in 2025 shows that only about 1% of patients who are prescribed opioids also receive a prescription for the opioid overdose reversal medication naloxone.3,4 While healthcare providers recognize the risks associated with opioids, it’s important for patients to understand them as well.3 Remind your patients who take prescription opioids that accidental overdoses can happen—even when prescription opioids are not misused.3 Make sure they know that anyone who takes opioids can be at risk for overdose and even death.3 Talk with them about the risks, and consider co-prescribing KLOXXADO® for your patients taking prescription opioids.5
Opioids can pose a risk to patients.3 Unintended drug interactions, accidentally taking multiple doses (or an incorrect dose) and pre-existing health conditions can all increase the likelihood of a potentially deadly opioid overdose.3 While many patients will probably heed your advice to avoid alcohol while taking prescription opioids, they may not be aware of the dangerous interactions that can occur between opioids and certain other prescription medications.6,7 Side effects of prescription opioids (drowsiness and confusion, for example) can be problematic as well.3 Patients taking prescription opioids could accidentally take too much after misreading a label or forgetting that they already took their medicine.3,8 Pre-existing conditions like sleep apnea or lung disease are another concern.9 Patients may not know that opioids can cause a potentially devastating slowdown in their breathing rate.9 And patients with certain liver or kidney conditions may not make the connection between existing health issues, how they metabolize their medications and how potential drug interactions may impact their risk of accidental opioid overdose.5,9
Opioids relieve pain by attaching to opioid receptors found on nerve cells throughout the body, including the brain.10 When opioids attach to the opioid receptors in the respiratory center of the brain, they can interfere with the body’s ability to breathe.9 Naloxone is a life-saving medication that can reverse the effects of an opioid overdose.11 KLOXXADO® Nasal Spray blocks the effects of opioids on the brain and can help restore normal breathing within two to three minutes.12 Additional doses may be needed if the patient is not adequately responding, or responds and then relapses back into respiratory depression.12
Naloxone, the active ingredient in KLOXXADO®, works only if a person has opioids in their system—it’s not harmful to use even if a person hasn’t taken opioids.12,13 The use of KLOXXADO® in patients who are opioid-dependent may precipitate opioid withdrawal.12 Although naloxone has no effect on a person who is not experiencing an opioid overdose, it can save a life in an actual opioid overdose emergency.13 KLOXXADO® is a prefilled, easy-to-use single-dose nasal spray, so anyone can be prepared to reverse an overdose at any time.12
Co-prescribing naloxone could be a matter of life and death for at-risk patients taking opioids for pain.4 In 2022, for example, there were close to 15,000 deaths involving prescription opioids.4 In spite of the risk of opioid overdose, only 1% of prescription opioid patients are co-prescribed naloxone.4
The CDC Clinical Practice Guideline for Prescribing Opioids for Pain—United States, 2022 support naloxone co-prescribing for patients at-risk who take prescription opioids.5 The Guidelines recommend naloxone because of the:5
The FDA maintains that naloxone is a medicine with no abuse potential, and it is not a controlled substance.14
In addition to co-prescribing naloxone to patients who are taking prescription opioids, healthcare providers should also educate caregivers and families on the importance of naloxone and how it can save a life in an emergency overdose situation.15
Given the lifesaving benefit of naloxone in an opioid overdose emergency, co-prescribing naloxone to patients who are prescribed opioids for pain management makes sense—especially for patients who:3
Every second counts in an opioid overdose emergency. Once a person stops breathing as a result of opioid overdose, brain damage can occur within four minutes.16 That’s why it’s so important to take action immediately—even before emergency services arrive.12,16 Teach family members and caregivers to recognize the signs of opioid overdose:12
Instruct family members and caregivers to take action with naloxone as soon as they suspect an opioid overdose—even if they are not sure—and to seek emergency medical assistance after the first dose of KLOXXADO® is given.11,12 KLOXXADO® is easy for anyone to use—no training is required.12 Because a person suffering an opioid overdose cannot give themselves naloxone, tell the patient to let their family members and caregivers know where it is stored.11
Talking with your patients about naloxone sounds like a simple task, but the reality is that these conversations might get a little uncomfortable.17,18 Below are some suggestions that may help support your conversations with patients prescribed opioids:17,18
Before your patient leaves the office, remind them to present their prescription for KLOXXADO® with their opioid medication prescription at the pharmacy. For more information about KLOXXADO®, including helpful patient resources and answers to frequently asked questions, visit KLOXXADO.com.
Please see the Full Prescribing Information and Medication Guide for KLOXXADO® for complete product details.
NOTE: This article was not written by a medical professional and is not intended to substitute for the guidance of a physician. These are not Emergent’s recommendations, but rather facts and data collected from various reliable medical sources. See below for a full list of resources and their attributing links.